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  <xs:element id="crbu_PercentageOfOtherPartySExpenses" abstract="false" name="PercentageOfOtherPartySExpenses" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crbu_FutureMilestonePayments" abstract="false" name="FutureMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_FutureContingentMilestonePayments" abstract="false" name="FutureContingentMilestonePayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_UpfrontCashPaymentReceivableUnderAgreement" abstract="false" name="UpfrontCashPaymentReceivableUnderAgreement" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_RevenueRecognitionMilestoneMethodPending" abstract="false" name="RevenueRecognitionMilestoneMethodPending" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_EquityMultipleAxis" abstract="true" name="EquityMultipleAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="crbu_EquityMultipleDomain" abstract="true" name="EquityMultipleDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_FiveTimesMember" abstract="true" name="FiveTimesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_TenTimesMember" abstract="true" name="TenTimesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_FifteenTimesMember" abstract="true" name="FifteenTimesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_SuccessPayment" abstract="false" name="SuccessPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_AccountsReceivableAdditions" abstract="false" name="AccountsReceivableAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_AccountsReceivableDeductions" abstract="false" name="AccountsReceivableDeductions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ContractWithCustomerAssetsAdditions" abstract="false" name="ContractWithCustomerAssetsAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ContractWithCustomerAssetsDeductions" abstract="false" name="ContractWithCustomerAssetsDeductions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ContractWithCustomerLiabilityAdditions" abstract="false" name="ContractWithCustomerLiabilityAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ContractWithCustomerLiabilityDeductions" abstract="false" name="ContractWithCustomerLiabilityDeductions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_LaboratoryEquipmentMember" abstract="true" name="LaboratoryEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_AccruedResearchAndDevelopmentExpenses" abstract="false" name="AccruedResearchAndDevelopmentExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_AccruedPatentExpensesCurrent" abstract="false" name="AccruedPatentExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_AccruedSublicensingFees" abstract="false" name="AccruedSublicensingFees" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_PrivateCompanyLicenseAgreementMember" abstract="true" name="PrivateCompanyLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_PfizerMember" abstract="true" name="PfizerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_SecuritiesPurchaseAgreementTerm" abstract="false" name="SecuritiesPurchaseAgreementTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="crbu_SecuritiesPurchaseAgreementPeriodOfRightOfFirstNegotiation" abstract="false" name="SecuritiesPurchaseAgreementPeriodOfRightOfFirstNegotiation" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="crbu_ContractWithCustomerLiabilityIncreaseForNewContract" abstract="false" name="ContractWithCustomerLiabilityIncreaseForNewContract" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_RightOfUseAssetMember" abstract="true" name="RightOfUseAssetMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_NumberOfAgreements" abstract="false" name="NumberOfAgreements" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="crbu_AtTheMarketATMOfferingMember" abstract="true" name="AtTheMarketATMOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_PublicStockOfferingMember" abstract="true" name="PublicStockOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_SaleOfStockAuthorizedAmountUnderShelfRegistration" abstract="false" name="SaleOfStockAuthorizedAmountUnderShelfRegistration" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_SaleOfStockAggregateGrossProceeds" abstract="false" name="SaleOfStockAggregateGrossProceeds" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ShelfRegistrationStatementAvailableForSale" abstract="false" name="ShelfRegistrationStatementAvailableForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_SaleOfStockNumberOfSharesRemainingAvailableAmount" abstract="false" name="SaleOfStockNumberOfSharesRemainingAvailableAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_IncentiveStockOptionsMember" abstract="true" name="IncentiveStockOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_PerformanceRestrictedStockUnitsPRSUMember" abstract="true" name="PerformanceRestrictedStockUnitsPRSUMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_A2021EquityIncentivePlanMember" abstract="true" name="A2021EquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_TwoThousandThirteenStockOptionPlanMember" abstract="true" name="TwoThousandThirteenStockOptionPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_EmployeeStockPurchasePlanTwoThousandTwentyOneMember" abstract="true" name="EmployeeStockPurchasePlanTwoThousandTwentyOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_CommonStockOutstandingPercentage" abstract="false" name="CommonStockOutstandingPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crbu_CashBasedCompensation" abstract="false" name="CashBasedCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_CommonStockCapitalSharesReservedForFutureIssuanceYearlyPercentageIncrease" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceYearlyPercentageIncrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crbu_PercentageOfEligibleEmployeeToPurchaseSharesOfCommonStockDiscount" abstract="false" name="PercentageOfEligibleEmployeeToPurchaseSharesOfCommonStockDiscount" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crbu_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crbu_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crbu_RestrictedStockUnitsRSUAndPerformanceBasedRSUsMember" abstract="true" name="RestrictedStockUnitsRSUAndPerformanceBasedRSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_SummaryOfIncomeTaxTable" abstract="true" name="SummaryOfIncomeTaxTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="crbu_FederalOrphanDrugCreditMember" abstract="true" name="FederalOrphanDrugCreditMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_IncomeTaxLineItems" abstract="true" name="IncomeTaxLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crbu_EffectiveIncomeTaxRateReconciliationReturnToProvisionFederal" abstract="false" name="EffectiveIncomeTaxRateReconciliationReturnToProvisionFederal" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crbu_EffectiveIncomeTaxRateReconciliationPriorYearCreditsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationPriorYearCreditsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crbu_EffectiveIncomeTaxRateReconciliationPriorYearCreditsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationPriorYearCreditsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_DeferredTaxAssetsOperatingLossCarryforwardsAndTaxAttributesCarryforwards" abstract="false" name="DeferredTaxAssetsOperatingLossCarryforwardsAndTaxAttributesCarryforwards" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_DeferredTaxAssetsTaxDeferredCapitalizedLicenseAndPatentCosts" abstract="false" name="DeferredTaxAssetsTaxDeferredCapitalizedLicenseAndPatentCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_DeferredTaxAssetsLeasedLiabilities" abstract="false" name="DeferredTaxAssetsLeasedLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_DeferredTaxAssetFixedAssets" abstract="false" name="DeferredTaxAssetFixedAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_DeferredTaxValuationRollForward" abstract="true" name="DeferredTaxValuationRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crbu_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_ExternalCosts" abstract="false" name="ExternalCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_InternalCosts" abstract="false" name="InternalCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ResearchAndDevelopmentExpenseAdjusted" abstract="false" name="ResearchAndDevelopmentExpenseAdjusted" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_GeneralAndAdministrativeExpenseAdjusted" abstract="false" name="GeneralAndAdministrativeExpenseAdjusted" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ResearchAndDevelopmentInternalCostsExcludingStockBasedCompensationExpense" abstract="false" name="ResearchAndDevelopmentInternalCostsExcludingStockBasedCompensationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ResearchAndDevelopmentInternalCostsExcludingDepreciationAndAmortizationExpenses" abstract="false" name="ResearchAndDevelopmentInternalCostsExcludingDepreciationAndAmortizationExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_GeneralAndAdministrativeExpenseExcludingStockBasedCompensation" abstract="false" name="GeneralAndAdministrativeExpenseExcludingStockBasedCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_GeneralAndAdministrativeExpenseExcludingDepreciationAndAmortization" abstract="false" name="GeneralAndAdministrativeExpenseExcludingDepreciationAndAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_CashSeveranceCostsBenefitsAndTransitionExpensesMember" abstract="true" name="CashSeveranceCostsBenefitsAndTransitionExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_SeveranceAndWindDownCostsMember" abstract="true" name="SeveranceAndWindDownCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crbu_RestructuringIncurredCostStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" abstract="false" name="RestructuringIncurredCostStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crbu_WindDownCosts" abstract="false" name="WindDownCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crbu_ImpairmentChargesMember" abstract="true" name="ImpairmentChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
