CARIBOU BIOSCIENCES, INC.
2929 7th Street
Berkeley, California 94710
August 12, 2022
United States Securities and Exchange Commission
Division of Corporate Finance
100 F Street, NE
Washington, D.C. 20549
Attention: Margaret Schwartz
Re: Caribou Biosciences, Inc. (the Registrant) - Request for Acceleration
Registration Statement on Form S-3
File No. 333- 266712
Ladies and Gentlemen:
Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, the Registrant hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333- 266712) (the Registration Statement), so that it may become effective at 4:00 p.m. Eastern Standard Time on Tuesday, August 16, 2022, or as soon thereafter as practicable.
The Registrant hereby authorizes each of Ashok Mukhey and Wendy Grasso of Reed Smith LLP, attorneys for the Registrant, to orally modify or withdraw this request for acceleration.
The Registrant requests that it be notified of such effectiveness by a telephone call to Ashok Mukhey at (310) 734-5291 or, in his absence, Wendy Grasso at (212) 549-0216.
|CARIBOU BIOSCIENCES, INC.|
/s/ Jason OByrne
|Title:||Chief Financial Officer|