United States securities and exchange commission logo August 11, 2022 Rachel E. Haurwitz, Ph.D. President and Chief Executive Officer Caribou Biosciences, Inc. 2929 7th Street, Suite 105 Berkeley, California 94710 Re: Caribou Biosciences, Inc. Registration Statement on Form S-3 Filed August 9, 2022 File No. 333-266712 Dear Dr. Haurwitz: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Margaret Schwartz at 202-551-7153 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Ashok W. Mukhey, Esq.